1-(1-Methyl(4-piperidyl))-6-nitroindoline → 1-(1-Methyl-4-piperidyl)-indoline-6-ylamine

HRID 2214208노트

반응식

HRID 2214208 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([N+:17]([O-])=O)[CH:15]=3)[CH2:10][CH2:9]2)[CH2:4][CH2:3]1>CO>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH2:17])[CH:15]=3)[CH2:10][CH2:9]2)[CH2:6][CH2:7]1

참가 물질

3

반응물 1

HCID 187966231-(1-Methyl(4-piperidyl))-6-nitroindoline

생성물 1

HCID 219595601-(1-Methyl-4-piperidyl)-indoline-6-ylamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-(1-Methyl(4-piperidyl))-6-nitroindoline (3 g, Step A) was dissolved in 100 mL MeOH and the mixture was bubbled with H2 for 10 min. 10% Pd/C (200 mg) was added and the mixture was stirred under H2 overnight. The mixture was filtered through Celite® and concentrated in vacuo to afford light yellow oil. MS: 232 (M+1) Calc'd. for C14H21N3—231.3.

후처리

  1. customthe mixture was bubbled with H2 for 10 min
  2. addition10% Pd/C (200 mg) was added
  3. filtrationThe mixture was filtered through Celite®
  4. concentrationconcentrated in vacuo
  5. customto afford light yellow oil

출처 및 근거

ORD 기록
ord-ca7aa9f0d32543efad55c03a88f78c01
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07105682B2

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