Ammonia → 4-amino-1-benzyl-3-nitro-1H-pyridin-2-one

HRID 2214448노트

반응식

HRID 2214448 반응식
[NH3:1].[CH2:2]([N:9]1[CH:14]=[CH:13][C:12](OCC2C=CC=CC=2)=[C:11]([N+:23]([O-:25])=[O:24])[C:10]1=[O:26])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>ClCCl>[NH2:1][C:12]1[CH:13]=[CH:14][N:9]([CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[C:10](=[O:26])[C:11]=1[N+:23]([O-:25])=[O:24]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 219476521-Benzyl-4-benzyloxy-3-nitro-pyridin-2-one

생성물 1

HCID 219476414-amino-1-benzyl-3-nitro-1H-pyridin-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

20 ml of a saturated ethanolic ammonia solution were added to a solution of 5.5 g (16.3 mmol) of 1-benzyl-4-benzyloxy-3-nitro-pyridin-2-one in 50 ml dichloromethane and stirred for 3 days at ambient temperature in the sealed flask. The solution was evaporated to dryness, the residue was triturated with diethyl ether, suction filtered and dried.

후처리

  1. customThe solution was evaporated to dryness
  2. customthe residue was triturated with diethyl ether, suction
  3. filtrationfiltered
  4. customdried

출처 및 근거

ORD 기록
ord-acf982725c804f048c9961e2e0d4844a
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109192B2

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