4-amino-1-benzyl-3-nitro-1H-pyridin-2-one → 3,4-diamino-1-benzyl-1H-pyridin-2-one

HRID 2214449노트

반응식

HRID 2214449 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:4](=[O:15])[C:3]=1[N+:16]([O-])=O>O1CCCC1.[Pt]=O>[CH2:8]([N:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[C:3]([NH2:16])[C:4]1=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 1

HCID 219476414-amino-1-benzyl-3-nitro-1H-pyridin-2-one

생성물 1

HCID 219476293,4-diamino-1-benzyl-1H-pyridin-2-one

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 8028Tetrahydrofuran용매

실험 절차

3.9 g (15.9 mmol) of 4-amino-1-benzyl-3-nitro-pyridin-2-one, dissolved in 250 ml of tetrahydrofuran, were hydrogenated over platinum oxide at 50 psi of H2 pressure and at ambient temperature. After the catalyst had been filtered off the filtrate was concentrated by evaporation and the residue was further processed in crude form.

후처리

  1. filtrationAfter the catalyst had been filtered off the filtrate
  2. concentrationwas concentrated by evaporation

출처 및 근거

ORD 기록
ord-f674d1a0772a4efb9347181944e7969b
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109192B2

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