o-Fluorobenzaldehyde → 2-Fluorobenzaldehyde o-methyloxime

반응식

[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[O:11]([NH2:13])[CH3:12]>>[CH3:12][O:11][N:13]=[CH:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[F:1]

참가 물질

반응물 2

HCID 67970o-Fluorobenzaldehyde

HCID 521874O-Methylhydroxylamine hydrochloride

생성물 1

HCID 738555822-Fluorobenzaldehyde o-methyloxime수율 98%

실험 절차

Reaction of 2-fluorobenzaldehyde with methoxylamine hydrochloride as described in the preparation of Compound 44-A gave the title oxime ether as a clear oil (98% yield). HPLC indicated a 91:9 mixture of E- to Z-isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): (E-isomer) 3.99 (3H, s, OCH3), 7.07 (1H, m, aromatic), 7.14 (1H, m, aromatic), 7.34 (1H, m, aromatic), 7.82 (1H, m, aromatic), 8.31 (1H, s, CH).

출처 및 근거

ORD 기록: ord-306580bc486842bb83d0fadced643576
출처 데이터셋: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07109186B2

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