O-Methylhydroxylamine hydrochloride → HCID 73855576, 화합물

HRID 2214565노트

반응식

HRID 2214565 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]=O)=[CH:4][CH:3]=1.Cl.[O:12]([NH2:14])[CH3:13]>>[CH3:13][O:12][N:14]=[CH:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1

참가 물질

3

반응물 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 111263222-(4-Fluorophenyl)acetaldehyde

생성물 1

HCID 73855576HCID 73855576, 화합물수율 43%

실험 절차

Reaction of 4-fluorophenylacetaldehyde with methoxylamine hydrochloride as described in the preparation of Compound 44-A gave the title oxime ether as a clear oil (43% yield). 1HNMR indicated a 1:1 mixture of E- to Z-isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): 3.51 (2H, d, J=6.7 Hz, CH2), 3.66 (2H, d, J=5.5 Hz, CH2), 3.88 (3H, s, OCH3), 3.96 (3H, s, OCH3), 6.79 (1H, t, J=5.5 Hz, CH), 7.03 (2H, m, aromatics), 7.19 (2H, m, aromatics), 7.45 (1H, t, J=6.7 Hz, CH).

출처 및 근거

ORD 기록
ord-0457bb0106d44e66a881ed7df0bb52f0
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109186B2

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