Bromine → 5-Bromo-2-hydroxypyridine-3-carbonitrile

HRID 2214739노트

반응식

HRID 2214739 반응식
[Br:1]Br.[O:3]=[C:4]1[C:9]([C:10]#[N:11])=[CH:8][CH:7]=[CH:6][NH:5]1>C(O)(=O)C>[Br:1][C:7]1[CH:8]=[C:9]([C:10]#[N:11])[C:4](=[O:3])[NH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 5775433-Cyano-2-pyridone

생성물 1

HCID 72048705-Bromo-2-hydroxypyridine-3-carbonitrile

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Bromine (29 ml, 560 mmol) was added to a stirred solution of 2-oxo-1,2-dihydro-pyridine-3-carbonitrile (34 g, 280 mmol) in acetic acid (180 ml) at room temperature. After 14 hours the reaction mixture was concentrated in vacuo and the resulting oil was trituated with ethanol to afford the title compound as a solid.

후처리

  1. concentrationAfter 14 hours the reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-88e0564d21944360a2cc532a9dc99ba6
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109199B2

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