Benzoyl isothiocyanate → (6-Methoxy-pyrazin-2-yl)-thiourea

HRID 2214764노트

반응식

HRID 2214764 반응식
[CH3:1][O:2][C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[N:5][CH:4]=1.C([N:18]=[C:19]=[S:20])(=O)C1C=CC=CC=1>C(O)C>[CH3:1][O:2][C:3]1[N:8]=[C:7]([NH:9][C:19]([NH2:18])=[S:20])[CH:6]=[N:5][CH:4]=1

참가 물질

4

반응물 2

HCID 68284Benzoyl isothiocyanateHCID 48681936-Methoxypyrazin-2-amine

생성물 1

HCID 21948402(6-Methoxy-pyrazin-2-yl)-thiourea

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

6-Methoxy-pyrazin-2-ylamine (0.85 g, 6.8 mmol) is dissolved in ethanol (7 ml) and benzoylisothiocyanate (0.91 ml) is added dropwise. The mixture is heated to 80° C. with stirring for 10 minutes then allowed to cool to room temperature. The solvent is removed in vacuo and the resulting solid dissolved in 1M sodium hydroxide (15 ml) and heated under reflux for 1 hour. The resultant suspension is filtered and the solid washed with water and a little cold ethanol. The solid is dried in vacuo to yield the title compound.

후처리

  1. temperatureto cool to room temperature
  2. customThe solvent is removed in vacuo
  3. dissolutionthe resulting solid dissolved in 1M sodium hydroxide (15 ml)
  4. temperatureheated
  5. temperatureunder reflux for 1 hour
  6. filtrationThe resultant suspension is filtered
  7. washthe solid washed with water
  8. customThe solid is dried in vacuo

출처 및 근거

ORD 기록
ord-8047c569232c418e9e7ea9481324df5a
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109202B2

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