Sodium Sulfate → HCID 11219349, 화합물

HRID 2214966노트

반응식

HRID 2214966 반응식
[NH2:1][C@H:2]1[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][C@H:3]1[F:15].[O-]S([O-])(=O)=O.[Na+].[Na+].[N:23]1[C:31]2[C:26](=[N:27][CH:28]=[C:29]([CH:32]=O)[CH:30]=2)[S:25][N:24]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(Cl)Cl.CCO>[F:15][C@@H:3]1[C@H:2]([NH:1][CH2:32][C:29]2[CH:30]=[C:31]3[N:23]=[N:24][S:25][C:26]3=[N:27][CH:28]=2)[CH2:7][CH2:6][NH:5][CH2:4]1

참가 물질

7

반응물 4

HCID 24436Sodium SulfateHCID 5049666Sodium triacetoxyborohydrideHCID 112644351,1-Dimethylethyl (3R,4S)-4-amino-3-fluoro-1-piperidinecarboxylateHCID 11355675[1,2,3]Thiadiazolo[5,4-b]pyridine-6-carbaldehyde

생성물 1

HCID 11219349HCID 11219349, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

A solution of cis-4-amino-1-tert-butoxycarbonyl-3-fluoropiperidine (1a) (1.00 mmole) in CH2Cl2 (5 mL) and EtOH (0.5 mL) is treated with anhydrous Na2SO4 (280 mg) and [1,2,3]thiadiazolo[5,4-b]pyridine-6-carboxaldehyde (1b) (1.10 mmole). The resulting solution is stirred at room temperature, then sodium triacetoxy borohydride (320 mg, 1.50 mmole) is added. The mixture is quenched by the addition of water (2 mL) and the volatiles removed in vacuo. Purification gives the desired compound.

후처리

  1. customThe mixture is quenched by the addition of water (2 mL)
  2. customthe volatiles removed in vacuo
  3. customPurification

출처 및 근거

ORD 기록
ord-88034d44eb614e7f9ae9cd02985f40b3
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109213B2

반응 노트

불러오는 중…