Phosgene → Methyl 2-oxooxazolidine-4-carboxylate

HRID 2215074

반응식

HRID 2215074 반응식
CC(CSC[C@H]1[O:11][C@@H:10](N2C3NC=NC(=O)C=3N=C2)[C@H](O)[C@@H]1O)C.Cl.[CH3:25][O:26][C:27](=[O:32])[C@H:28]([CH2:30][OH:31])[NH2:29].C(Cl)(Cl)=O>>[CH3:25][O:26][C:27]([CH:28]1[CH2:30][O:31][C:10](=[O:11])[NH:29]1)=[O:32]

참가 물질

4

반응물 3

HCID 6371PhosgeneHCID 2723730L-Serine, methyl ester, hydrochloride (1:1)HCID 178454970HCID 178454970, 화합물

생성물 1

HCID 500251Methyl 2-oxooxazolidine-4-carboxylate

실험 절차

The preparation of 1-1 was carried out according to the literature procedure (see: Sibi, M. P. et al, J. Chem. Soc. Perkin Trans. 1 1994, 1675). Thus, 39.5 grams of serine methyl ester hydrochloride was reacted with phosgene (20% solution in toluene, 175 mL) to give 42 grams of desired product. 1H NMR (400 MHz, acetone-d6): δ 7.1 (br s, 1H, NH), 4.64–4.56 (m, 2H), 4.44 (dd, 1H), 3.77 (s, 3H).

후처리

  1. customThe preparation of 1-1

출처 및 근거

ORD 기록
ord-3fdd557e92d0439d88e25cfc3b72aaf9
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109223B2

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