Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanogen Bromide → 2-Aminobenzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanogen Bromide | HCID 10476 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3-Methoxybenzene-1,2-diamine | HCID 184268 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Aminobenzimidazole | HCID 13624 | — |
반응 단계
Cyanogen bromide (7.05 mmol, 0.74 g) was added to a solution of 2,3-diaminoanisole (4.7 mmol, 0.65 g) in EtOH (10 mL) and the reaction was stirred at room temperature for 14 h. The reaction was diluted with H2O and then basified (pH>12) using 4 M NaOH. The aqueous layer was extracted with CH2Cl2. The organic phase was then separated and washed with brine and then dried over MgSO4 and then concentrated to provide 2-aminobenzimidazole 37b.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08207173B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-4dd7d82b92d54646aeddc463d3d6f37d |
| 출처 메모 | uspto-grants-2012_06 |