Ethyl Acetate → 5-Nitroquinoline-2-carbaldehyde

HRID 2215434노트

반응식

HRID 2215434 반응식
I([O-])(=O)(=O)=O.[Na+].OC([N:11]1[C:20]2[C:15](=[C:16]([N+:21]([O-:23])=[O:22])[CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH2:12]1)CO.[C:24](OCC)(=[O:26])C>O1CCCC1.O>[N+:21]([C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:15]=1[CH:14]=[CH:13][C:12]([CH:24]=[O:26])=[N:11]2)([O-:23])=[O:22]

참가 물질

6

반응물 3

HCID 8857Ethyl AcetateHCID 21948859HCID 21948859, 화합물HCID 23667635Sodium periodate

생성물 1

HCID 47370745-Nitroquinoline-2-carbaldehyde

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

2.99 g (14.0 mmol) of sodium periodate is added to a solution that consists of 1.64 g (7.0 mmol) of 1-(1,2-dihydroxyethyl)-5-nitroquinoline in 42 ml of tetrahydrofuran and 7.0 ml of water. After 20 hours at room temperature, ethyl acetate is added, and the organic phase is washed with saturated sodium chloride solution. After the organic phase is dried on sodium sulfate, after the solvent is removed, and after purification on silica gel with hexane-ethyl acetate (0–100%), 1.40 g (99% of theory) of the product is obtained.

후처리

  1. washthe organic phase is washed with saturated sodium chloride solution
  2. customAfter the organic phase is dried on sodium sulfate
  3. customafter the solvent is removed
  4. customafter purification on silica gel with hexane-ethyl acetate (0–100%), 1.40 g (99% of theory) of the product
  5. customis obtained

출처 및 근거

ORD 기록
ord-b024dfcfc8764223953455c105a08240
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109212B2

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