Methylamine → HCID 21948911, 화합물

반응식

CO[C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:15])[N:6]=1)=[O:4].[CH3:16][NH2:17]>>[CH3:16][NH:17][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:15])[N:6]=1)=[O:4]

참가 물질

반응물 2

HCID 6329Methylamine

HCID 45089604Methyl 5-aminoquinoline-2-carboxylate

생성물 1

HCID 21948911HCID 21948911, 화합물

실험 절차

76 mg (0.376 mmol) of 5-aminoquinoline-2-carboxylic acid methyl ester is dissolved with 10 ml of a 2.0 M methanolic methylamine solution. After 90 minutes under reflux and another 16 hours at room temperature, the solvent is removed under reduced pressure, and the residue is purified on silica gel with hexane-ethyl acetate (0–80%). 72 mg (95% of theory) of the product is obtained.

후처리

customthe solvent is removed under reduced pressure
customthe residue is purified on silica gel with hexane-ethyl acetate (0–80%)
custom72 mg (95% of theory) of the product is obtained

출처 및 근거

ORD 기록: ord-436b0a7970654ebc8db50c8dedbb1567
출처 데이터셋: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07109212B2

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