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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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4-(5-Fluoro-2-methoxy-phenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal → 5-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentylidenamino]quinoline-2-carboxylic acid diethylamide

HRID 2215459
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인쇄 미리보기

반응식

HRID 2215459 반응식
[CH2:1]([N:3]([CH2:17][CH3:18])[C:4]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[NH2:16])[N:7]=1)=[O:5])[CH3:2].[F:19][C:20]1[CH:21]=[CH:22][C:23]([O:38][CH3:39])=[C:24]([C:26]([CH3:37])([CH3:36])[CH2:27][C:28]([OH:35])([C:31]([F:34])([F:33])[F:32])[CH:29]=O)[CH:25]=1>O1CCCC1.[Ti]>[CH2:17]([N:3]([CH2:1][CH3:2])[C:4]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[N:16]=[CH:29][C:28]([OH:35])([C:31]([F:32])([F:34])[F:33])[CH2:27][C:26]([C:24]2[CH:25]=[C:20]([F:19])[CH:21]=[CH:22][C:23]=2[O:38][CH3:39])([CH3:36])[CH3:37])[N:7]=1)=[O:5])[CH3:18]
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참가 물질

5

반응물 2

HCID 115731224-(5-Fluoro-2-methoxy-phenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanalHCID 69203919HCID 69203919, 화합물

생성물 1

HCID 692051715-[4-(5-Fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentylidenamino]quinoline-2-carboxylic acid diethylamide

시약·촉매·용매 2

HCID 23963Titanium촉매HCID 8028Tetrahydrofuran
용매

실험 절차

A solution that consists of 210 mg (0.86 mmol) of 5-aminoquinoline-2-carboxylic acid diethylamide, 266 mg (0.86 mmol) of 4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal and 0.36 ml (1.73 mmol) of titanium tetraethylate in 15 ml of tetrahydrofuran is stirred for one hour at room temperature and then for 3 hours at 80° C. After removal of the solvent and purification on silica gel with hexane-ethyl acetate (0–70%), 230 mg (52% of theory) of the product is obtained.

후처리

  1. waitfor 3 hours at 80° C
  2. customAfter removal of the solvent and purification on silica gel with hexane-ethyl acetate (0–70%), 230 mg (52% of theory) of the product
  3. customis obtained

출처 및 근거

ORD 기록
ord-24096dcbdb934fed9cec4a01ccf947af
출처 데이터셋
uspto-grants-2006_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07109212B2

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