Piperidine → N1-Ethyl-5-(2-(piperidin-1-ylcarbonyl)amino-4-pyridyl)oxy-1H-1-indolecarboxamide

HRID 2215537노트

반응식

HRID 2215537 반응식
N1CCCCC1.C(NC(N1C2C(=CC(OC3C=CN=C(NC(=O)OC4C=CC=CC=4)C=3)=CC=2)C=C1)=O)C.[CH2:38]([NH:40][C:41]([N:43]1[C:51]2[C:46](=[CH:47][C:48]([O:52][C:53]3[CH:58]=[CH:57][N:56]=[C:55]([NH:59][C:60]([N:62]4[CH2:67][CH2:66][CH:65](N5CCCC5)[CH2:64][CH2:63]4)=[O:61])[CH:54]=3)=[CH:49][CH:50]=2)[CH:45]=[CH:44]1)=[O:42])[CH3:39]>CN(C)C=O>[CH2:38]([NH:40][C:41]([N:43]1[C:51]2[C:46](=[CH:47][C:48]([O:52][C:53]3[CH:58]=[CH:57][N:56]=[C:55]([NH:59][C:60]([N:62]4[CH2:67][CH2:66][CH2:65][CH2:64][CH2:63]4)=[O:61])[CH:54]=3)=[CH:49][CH:50]=2)[CH:45]=[CH:44]1)=[O:42])[CH3:39]

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 9982436N1-Ethyl-5-(2-(((4-(pyrrolidin-1-yl)piperidin-1-yl)carbonyl)amino)pyridin-4-yloxy)-1H-1-indolecarboxamideHCID 21949099Phenyl N-(4-(1-(ethylamino)carbonyl-1H-5-indolyl)oxy-2-pyridyl)carbamate

생성물 1

HCID 10409125N1-Ethyl-5-(2-(piperidin-1-ylcarbonyl)amino-4-pyridyl)oxy-1H-1-indolecarboxamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N,N-Dimethylformamide (4 ml) and piperidine (0.31 ml, 3.13 mmol) were added to a mixture (0.336 g) of phenyl N-(4-(1-(ethylamino)carbonyl-1H-5-indolyl)oxy-2-pyridyl)carbamate and phenyl N-(4-(1-(ethylamino)carbonyl-1H-5-indolyl)oxy-2-pyridyl)-N-(phenoxycarbonyl)carbamate obtained in Example 77; the reaction mixture was stirred overnight; the reaction mixture was partitioned between ethyl acetate and water; and the organic layer was concentrated to yield the title compound as crystals (182 mg, 0.45 mmol).

후처리

  1. customthe reaction mixture was partitioned between ethyl acetate and water
  2. concentrationand the organic layer was concentrated

출처 및 근거

ORD 기록
ord-fbf4d0ef11d94e5581ec6d4335b76592
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109219B2

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