Triethylamine → 2-Chloro-6-(4-chlorobenzylamino)purine

HRID 2215650노트

반응식

HRID 2215650 반응식
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.C(N(CC)CC)C.[Cl:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24][NH2:25])=[CH:22][CH:21]=1>C(O)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH:25][CH2:24][C:23]2[CH:26]=[CH:27][C:20]([Cl:19])=[CH:21][CH:22]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 660364-ChlorobenzylamineHCID 53244122,6-Dichloropurine

생성물 1

HCID 219518362-Chloro-6-(4-chlorobenzylamino)purine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

To a suspension of 15 g (0.0794 mol) of 2,6-dichloropurine in 250 mL of absolute ethanol was added 12.7 mL (0.0873 mol) of triethylamine and 10.62 mL (0.0873 mol) of 4-chlorobenzylamine. The mixture was refluxed at 80° C. for 16 h (the formation of creamy white precipitate was observed). The reaction mixture was cooled and the precipitated product was removed by filtration. The precipitate was washed with ethanol (350 mL) and dried in high vacuum for 24 h. Product was characterized by 1H-NMR.

후처리

  1. temperatureThe reaction mixture was cooled
  2. customthe precipitated product was removed by filtration
  3. washThe precipitate was washed with ethanol (350 mL)
  4. customdried in high vacuum for 24 h

출처 및 근거

ORD 기록
ord-925ebb556e1b4c25803035cfbabc0183
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109330B2

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