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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2215932생성일: 2026년 10월 26일

(4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester → (4aS,9bR)-8-butyl-5-methyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole-6-carbonitrile

https://huagongshe.com/reaction/2215932

반응식

참여 물질

역할이름HCID투입량
반응물(4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl esterHCID 58700289—
반응물HCID 178448256HCID 178448256—
촉매HCID 178418397HCID 178418397—
생성물(4aS,9bR)-8-butyl-5-methyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole-6-carbonitrileHCID 58700278—

반응 단계

Following the general procedure for Example 127–146, the title compound was prepared (8 mg, 30%) as a light yellow oil using (4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (Example 158, 40 mg, 0.10 mmol), n-butylzinc bromide (0.5 M in THF, 2.5 mole equivalent) and Pd(PPh3)4 (0.06 mole equivalent).: MS (ESI): 270 (base, M+H).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07109339B2
출처 데이터셋uspto-grants-2006_09
ORD IDord-f1ba21e7c57e40559d0b832afef8c6ef
출처 메모uspto-grants-2006_09