Trifluoroacetic acid → 4-(3-Bromo-5-hydroxy-benzenesulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester

HRID 2215992노트

반응식

HRID 2215992 반응식
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]([C:12]1[S:13][C:14]([S:32][CH3:33])=[C:15]([S:17]([C:20]2[CH:25]=[C:24]([O:26]C(C)(C)C)[CH:23]=[C:22]([Br:31])[CH:21]=2)(=[O:19])=[O:18])[CH:16]=1)=[O:11]>C(Cl)Cl>[CH3:8][O:9][C:10]([C:12]1[S:13][C:14]([S:32][CH3:33])=[C:15]([S:17]([C:20]2[CH:25]=[C:24]([OH:26])[CH:23]=[C:22]([Br:31])[CH:21]=2)(=[O:18])=[O:19])[CH:16]=1)=[O:11]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 210571734-(3-Bromo-5-tert-butoxy-benzenesulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester

생성물 1

HCID 210571774-(3-Bromo-5-hydroxy-benzenesulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester수율 101.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (5 mL) was added to a solution of 4-(3-bromo-5-tert-butoxy-benzenesulfonyl)-5-methylsulfanyl-thiophene-2-carboxylic acid methyl ester ((Example 12: step c) 240 mg, 0.5 mmol) in DCM (5 mL). The solution was stirred at rt for 2 h and the solvents were removed in vacuo, yielding 214 mg of an oil (quantitative) which was used without further purification.

후처리

  1. customthe solvents were removed in vacuo

출처 및 근거

ORD 기록
ord-8035297caa5743db980510f2c7493167
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109354B2

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