Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Amino-2-methyl-5-pyrimidinemethanamine → 4-{6-[(4-Amino-pyrimidin-5-ylmethyl)-amino]-5-bromo-pyridine-3-sulfonyl}-5-methylsulfanyl-thiophene-2-carboxamidine trifluoroacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Amino-2-methyl-5-pyrimidinemethanamine | HCID 66762 | — |
| 반응물 | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| 반응물 | tert-butyl N-[4-[(5-bromo-6-chloro-3-pyridinyl)sulfonyl]-5-methylsulfanylthiophene-2-carboximidoyl]carbamate | HCID 140043501 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-{6-[(4-Amino-pyrimidin-5-ylmethyl)-amino]-5-bromo-pyridine-3-sulfonyl}-5-methylsulfanyl-thiophene-2-carboxamidine trifluoroacetate | HCID 21886450 | — |
반응 단계
The reaction was conducted following the procedure for Example 164: step c, using {[4-(5-bromo-6-chloro-pyridine-3-sulfonyl)-5-methylsulfanyl-thiophen-2-yl]-imino-methyl}-carbamic acid tert-butyl ester (0.035 g, 0.067 mmol), 4-amino-5-aminomethyl-2-methylpyrimidine (0.018 g, 0.135 mmol), THF [2 mL], followed by DCM/TFA (1:1) and reverse-phase HPLC to yield the title compound. ESI-MS (m/z): Calcd. for C18H19BrN6O2S3: 528.48 (M+H); found 528.0, 529.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07109354B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-7b4d4ea3689b47a69936d134fa6fc0ff |
| 출처 메모 | uspto-grants-2006_09 |