Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
18-Crown-6 → 7-[(4,6-Dimethoxy-pyrimidin-2-yl)oxy]-3-fluoro-phthalide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 18-Crown-6 | HCID 28557 | — |
| 반응물 | Potassium Fluoride | HCID 522689 | — |
| 반응물 | 3-Chloro-7-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-phthalide | HCID 19927406 | — |
| 생성물 | 7-[(4,6-Dimethoxy-pyrimidin-2-yl)oxy]-3-fluoro-phthalide | HCID 19927451 | — |
반응 단계
A mixture of 1.0 g of 3-chloro-7-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-phthalide (see Example 85) and 0.19 g of spray-dried potassium fluoride and a spatula tip of 18-crown-6 is heated at reflux temperature for 100 minutes. The mixture is then filtered over Celite® and is concentrated by evaporation, and the crude product is recrystallised from ethyl acetate/n-hexane to yield 7-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-3-fluoro-phthalide, m.p. 172°-174° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428002 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-fa7b0110ae764beba36ccd7ed7b688fd |
| 출처 메모 | uspto-grants-1995_06 |