Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 4-(tert-Butyldimethylsiloxy)phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | p-Hydroxyphenyl benzoate | HCID 75549 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(tert-Butyldimethylsiloxy)phenol | HCID 597388 | — |
반응 단계
4-Hydroxyphenyl benzoate (9.0 mmol) was dissolved in CH2Cl2 (9 mL/mmol), TBDMS-Cl (1.5 eq., 13.5 mmol) and imidazole (2.0 eq., 18.0 mmol) were added and the mixture was stirred at r.t. overnight. The mixture was diluted with MeOH (4.5 mL/mmol), and NaBH4 (2.5 eq., 22.5 mmol) was added slowly over 5 min (attention: vigorous gas evolution). The mixture was concentrated by removing CH2Cl2 under reduced pressure and the suspension was heated to 65° C. for 15 h.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08207174B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-76d530adac7142d98b992c5740c45a81 |
| 출처 메모 | uspto-grants-2012_06 |