Potassium Carbonate → HCID 21942288, 화합물

HRID 2216359노트

반응식

HRID 2216359 반응식
CS(O[CH2:6][C@H:7]1[C@@H:9]([CH2:10]OS(C)(=O)=O)[O:8]1)(=O)=O.[Br:16][C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][CH:23]=1)[NH2:20].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:16][C:17]1[CH:18]=[C:19]([N:20]2[CH2:10][CH:9]3[O:8][CH:7]3[CH2:6]2)[CH:21]=[CH:22][CH:23]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 115623-BromoanilineHCID 86591773HCID 86591773, 화합물

생성물 1

HCID 21942288HCID 21942288, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
110 °C

실험 절차

A mixture of 5.4 g of cis-2,3-bis(methanesulfonyloxymethyl)oxirane, 2 ml of 3-bromoaniline, 4.3 g of anhydrous potassium carbonate and 30 ml of N,N-dimethylformamide was stirred under nitrogen atmosphere at 60° C. for 2 hours and at 110° C. for 2 hours. The reaction mixture was extracted with ethyl acetate-water, and the organic layer was washed with water and brine, dried over anhydrous magnesium sulfate and then evaporated. The residue was purified by silica gel column chromatography with 5–10% ethyl acetate/hexane, to give 420 mg of the title compound.

후처리

  1. extractionThe reaction mixture was extracted with ethyl acetate-water
  2. washthe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customevaporated
  5. customThe residue was purified by silica gel column chromatography with 5–10% ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-0cb2c59eb93244c78d57d6d38bed98fc
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07112593B2

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