Ammonium Chloride → 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

HRID 2216567노트

반응식

HRID 2216567 반응식
CO[C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1.[Cl-:11].[NH4+:12]>C(O)C>[ClH:11].[NH2:12][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1

참가 물질

4

반응물 2

HCID 25517Ammonium ChlorideHCID 219414705-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one

생성물 1

HCID 219413655-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 5-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one (2.3 g) and ammonium chloride (936 mg) in dry ethanol (32 mL) was stirred at room temperature for 1 h and then refluxed for 2 h. The reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was triturated with chloroform at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride was obtained as a pale brown powder (1.7 g, 66%).

후처리

  1. temperaturerefluxed for 2 h
  2. temperatureThe reaction mixture was cooled to room temperature
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with chloroform at room temperature for 30 min
  5. filtrationThe precipitate was filtered off
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-b0fe5107481641fdb832ad186f8ed23a
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07112582B2

반응 노트

불러오는 중…