Potassium Carbonate → 5-Amino-1-methyl-1,6-dihydropyrazin-2(3H)-one

HRID 2216568노트

반응식

HRID 2216568 반응식
Cl.[NH2:2][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:2][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 219413655-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

생성물 1

HCID 219413665-Amino-1-methyl-1,6-dihydropyrazin-2(3H)-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride (662 mg) in methanol (10 mL) was added 10% potassium carbonate aqueous solution at 0□ and then stirred for 40 min at 0□. The mixture was concentrated under reduced pressure. The residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The compound was obtained as a pale brown powder (515 mg, quantitative).

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customThe residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min
  3. filtrationThe precipitate was filtered off
  4. customdried in vacuo
  5. customThe compound was obtained as a pale brown powder (515 mg, quantitative)

출처 및 근거

ORD 기록
ord-2c8307f49cac406a9277db72a8f78c75
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07112582B2

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