Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 1H-Imidazol-1-ylphenylmethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Bifonazole | HCID 2378 | — |
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 생성물 | 1H-Imidazol-1-ylphenylmethanone | HCID 66319 | 74.7% |
반응 단계
Bifonazole has also been prepared by benzoylation of imidazole with PhCOCl, yielding 74.7% of 1-benzoylimidazole which is subject to react with Gringnard's reactant 4-PhC6H4MgBr followed by a tosylation and subsequent reduction with sodium cyanoborohydride in hexamethylphosphoramide, to yield 68.2% Bifonazole (Es. Patent 539,345).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07112681B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-14a305893a92494cbbdb94af5aff3359 |
| 출처 메모 | uspto-grants-2006_09 |