Morpholine → HCID 69103534, 화합물

HRID 2217260노트

반응식

HRID 2217260 반응식
[NH2:1][C:2]1[N:3]=[C:4]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:5]([C:9]2[CH:10]=[CH:11][C:12](=[O:18])[N:13]([CH:15]([CH3:17])[CH3:16])[CH:14]=2)=[N:6][C:7]=1Br.[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1.CN1C(=O)CCC1.CCOC(C)=O>O>[NH2:1][C:2]1[N:3]=[C:4]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:5]([C:9]2[CH:10]=[CH:11][C:12](=[O:18])[N:13]([CH:15]([CH3:17])[CH3:16])[CH:14]=2)=[N:6][C:7]=1[N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1

참가 물질

6

반응물 4

HCID 8083MorpholineHCID 8857Ethyl AcetateHCID 13387N-methyl-2-pyrrolidoneHCID 11429076HCID 11429076, 화합물

생성물 1

HCID 69103534HCID 69103534, 화합물수율 82.7%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
150 °C

실험 절차

A mixture of 5-(5-amino-6-bromo-3-phenyl-2-pyrazinyl)-1-isopropyl-2(1H)-pyridone (100 mg), morpholine (113 mg), and NMP (1.0 ml) was heated at 150° C. with stirring for 1 day. After cooling, EtOAc and water were poured into the mixture, and the organic layer was separated, washed with water and brine, and dried over MgSO4. The solvent was removed under reduced pressure, and the residue was recrystallized from MeOH-IPE and dried in vacuo to give 5-[5-amino-6-(4-morpholinyl)-3-phenyl-2-pyrazinyl]-1-isopropyl-2(1H)-pyridone (84 mg).

후처리

  1. temperatureAfter cooling
  2. customthe organic layer was separated
  3. washwashed with water and brine
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed under reduced pressure
  6. customthe residue was recrystallized from MeOH-IPE
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-fc646ac706ff4999893553499ce78cdb
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07407961B2

반응 노트

불러오는 중…