Trifluoroacetic acid → (2R,4R)-4-[(4-Methoxy-pyrrolidine-2-carbonyl)-amino]-benzoic acid methyl ester

HRID 2217478노트

반응식

HRID 2217478 반응식
C(OC([N:8]1[CH2:12][C@H:11]([O:13][CH3:14])[CH2:10][C@@H:9]1[C:15](=[O:27])[NH:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([O:25][CH3:26])=[O:24])=[CH:19][CH:18]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:26][O:25][C:23](=[O:24])[C:20]1[CH:19]=[CH:18][C:17]([NH:16][C:15]([C@H:9]2[CH2:10][C@@H:11]([O:13][CH3:14])[CH2:12][NH:8]2)=[O:27])=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68808041(2R,4R)-4-Methoxy-2-(4-methoxycarbonyl-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 68815558(2R,4R)-4-[(4-Methoxy-pyrrolidine-2-carbonyl)-amino]-benzoic acid methyl ester수율 100.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Into a solution of 7 (12.5 g, 33.0 mmol) in anhydrous CH2Cl2 (70 mL) was added TFA (20 mL). The solution was stirred at RT overnight before concentrating under reduced pressure to give 8 (9.19 g, 100%).

후처리

  1. concentrationbefore concentrating under reduced pressure

출처 및 근거

ORD 기록
ord-6fa6bd54989d424f85fd8eb4960eed09
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07407972B2

반응 노트

불러오는 중…