Cyclohexanepropanoic acid → N-(2,6-Dichloro-5-quinolinyl)-cyclohexanepropanamide

HRID 2217894노트

반응식

HRID 2217894 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([NH2:12])=[C:7]([Cl:13])[CH:6]=[CH:5][C:4]=2[N:3]=1.[CH:14]1([CH2:20][CH2:21][C:22](O)=[O:23])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:13])[C:8]=2[NH:12][C:22](=[O:23])[CH2:21][CH2:20][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:3]=1

참가 물질

3

반응물 2

HCID 69702Cyclohexanepropanoic acidHCID 248203742,6-Dichloroquinolin-5-amine

생성물 1

HCID 86012849N-(2,6-Dichloro-5-quinolinyl)-cyclohexanepropanamide

실험 절차

Prepared according to the method of example 62(a), using 2,6-dichloroquinolin-5-amine (example 1(d)) (0.5 g) and cyclohexanepropionic acid (1.2 mL). The resulting precipitate was filtered and washed with acetone. The precipitate was further washed with water and then ether to give the sub-title compound as a solid (0.248 g)

후처리

  1. customPrepared
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with acetone
  4. washThe precipitate was further washed with water

출처 및 근거

ORD 기록
ord-a3b9ff56b53c43c195568aaeca3bbc90
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07408065B2

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