HCID 11651470, 화합물 → HCID 136119393, 화합물
반응식
ClC1C=CC2N=C(C)C=CC=2C=1[C:13](O)=[O:14].[NH2:16][C:17](=[N:47][OH:48])[CH2:18][CH2:19][O:20][C@H:21]1[CH2:25][CH2:24][N:23]([C:26]2[CH:35]=[CH:34][C:33]3[C:28](=[CH:29][CH:30]=[C:31]([Cl:46])[C:32]=3[NH:36][C:37](=[O:45])[CH2:38][CH:39]3[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]3)[N:27]=2)[CH2:22]1>>[Cl:46][C:31]1[C:32]([NH:36][C:37](=[O:45])[CH2:38][CH:39]2[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]2)=[C:33]2[C:28](=[CH:29][CH:30]=1)[N:27]=[C:26]([N:23]1[CH2:24][CH2:25][C@H:21]([O:20][CH2:19][CH2:18][C:17]3[NH:16][C:13](=[O:14])[O:48][N:47]=3)[CH2:22]1)[CH:35]=[CH:34]2참가 물질
3
실험 절차
Prepared according to the method of Example 102 (b) using N-[2-[(3S)-3-[[3-amino-3-(hydroxyimino)propyl]oxy]-1-pyrrolidinyl]-6-chloro-5-quinolinyl]-cyclohexaneacetamide (Example 108 (a)) (200 mg). Purification (SiO2, methanol:dichloromethane 2:98 as eluant) gave the title compound as a solid (20 mg).
후처리
- customPrepared
- customPurification (SiO2, methanol:dichloromethane 2:98 as eluant)
출처 및 근거
- ORD 기록
- ord-28e517081fa046188d1456098b00dbde
- 출처 데이터셋
- uspto-grants-2008_08