Stannous chloride dihydrate → 3-amino-4-[(3-thienylmethyl)amino]-N,N-bis(2,2,2-trifluoroethyl)benzamide

HRID 2217942노트

반응식

HRID 2217942 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:20]=[CH:21][C:22]=1[NH:23][CH2:24][C:25]1[CH:29]=[CH:28][S:27][CH:26]=1)[C:7]([N:9]([CH2:15][C:16]([F:19])([F:18])[F:17])[CH2:10][C:11]([F:14])([F:13])[F:12])=[O:8])([O-])=O.O.O.[Sn](Cl)Cl>CN(C=O)C>[NH2:1][C:4]1[CH:5]=[C:6]([CH:20]=[CH:21][C:22]=1[NH:23][CH2:24][C:25]1[CH:29]=[CH:28][S:27][CH:26]=1)[C:7]([N:9]([CH2:15][C:16]([F:17])([F:18])[F:19])[CH2:10][C:11]([F:13])([F:14])[F:12])=[O:8]

참가 물질

4

반응물 2

HCID 61436Stannous chloride dihydrateHCID 588744973-Nitro-4-[(3-thienylmethyl)amino]-N,N-bis(2,2,2-trifluoroethyl)benzamide

생성물 1

HCID 588744803-amino-4-[(3-thienylmethyl)amino]-N,N-bis(2,2,2-trifluoroethyl)benzamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Same procedure used as above using 3-nitro-4-[(3-thienylmethyl)amino]-N,N-bis(2,2,2-trifluoroethyl)benzamide (138 mg, 0.312 mmol) and tin(II) chloride dihydrate (210 mg, 0.936 mmol) in 5 mL of DMF. Yield: 125 mg (97%); MS (ESI) 412.08 (MH+).

출처 및 근거

ORD 기록
ord-327adbd3fe77400b8613a78efb622dec
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07407968B2

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