Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2217964생성일: 2026년 10월 26일
Ethyl 5-aminopyridazine-4-carboxylate → 5-[2-(2,4,6-Trifluorophenyl)-acetylamino]-pyridazine-4-carboxylic acid ethyl ester
https://huagongshe.com/reaction/2217964
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl 5-aminopyridazine-4-carboxylate | HCID 12352298 | — |
| 반응물 | 2,4,6-Trifluorophenylacetyl chloride | HCID 57428015 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-[2-(2,4,6-Trifluorophenyl)-acetylamino]-pyridazine-4-carboxylic acid ethyl ester | HCID 68939424 | 101.7% |
반응 단계
5-Aminopyridazine-4-carboxylic acid ethyl ester (1.26 g, prepared according to J. Het. Chem., (1968), 5, 845) was dissolved in dry toluene (125 ml) at 90° C., and DMAP (0.92 g) was added. 2,4,6-Trifluorophenylacetyl chloride (1.75 g of 95% purity material) was added dropwise with stirring at 70° C., and a white solid precipitated. The reaction was stirred at reflux for 5 hours and then filtered hot. The filtrate was evaporated to give 5-[2-(2,4,6-trifluorophenyl)-acetylamino]-pyridazine-4-carboxylic acid ethyl ester as a white solid (2.6 g), m.p. 143-144° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07410967B2 |
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| 출처 데이터셋 | uspto-grants-2008_08 |
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| ORD ID | ord-00ec7cec4a364349b01b9e1274154ad2 |
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| 출처 메모 | uspto-grants-2008_08 |
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