Boron tribromide → HCID 17981923, 화합물

반응식

B(Br)(Br)Br.[F:5][C:6]1[C:14]2[CH2:13][CH2:12][S:11][C:10]=2[C:9]([O:15]C)=[CH:8][CH:7]=1.OC1C2N=CSC=2C=CC=1>>[F:5][C:6]1[C:14]2[CH2:13][CH2:12][S:11][C:10]=2[C:9]([OH:15])=[CH:8][CH:7]=1

참가 물질

반응물 3

HCID 25134Boron tribromide

HCID 819014-Hydroxybenzothiazole

HCID 179819214-Fluoro-7-methoxy-2,3-dihydrobenzo[b]thiophene

생성물 1

HCID 17981923HCID 17981923, 화합물

실험 절차

A BBr3 demethylation of 4-fluoro-7-methoxy-2,3-dihydrobenzo[b]thiophene similar to that described for 4-hydroxy benzothiazole affords the title compound as a brown solid 251 mg: δH (300 MHz, CDCl3) 6.57-6.48 (2H, m, ArH), 4.67 (1H, br. s, OH) and 3.43-3.23 (4H, m, SCH2CH2).

출처 및 근거

ORD 기록: ord-73daa662d70a42a0b3200741aa0e48a7
출처 데이터셋: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07410982B2

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