Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4,5-Dichloro-3-hydroxypyridazine | HCID 73247 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Bromomethyl methyl ether | HCID 83093 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one | HCID 12351834 | 74.8% |
반응 단계
To a stirred solution of 4,5-dichloropyridazin-6-one (5.00 g, 30.3 mmol) and N,N-diisopropylethylamine (7.92 mL, 45.5 mmol) in methylenechloride (50 mL) was added slowly, bromomethyl methyl ether (4.79 mL, 60.6 mmol) at room temperature (water-bath). The reaction was stirred for 22 h and was then concentrated. Purification by column chromatography (1% MeOH in CH2Cl2) gave 4.74 g (74.8%) of 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08207168B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-ae0fd16c91574504896206a7ea4213f6 |
| 출처 메모 | uspto-grants-2012_06 |