(4-Methoxyphenyl)hydrazine → 3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-amine

반응식

[NH2:1][C:2]1[N:6]([C:7]2[CH:15]=[CH:14][C:10](C(O)=O)=[CH:9][CH:8]=2)[N:5]=[C:4]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:3]=1.[CH3:20][O:21]C1C=CC(NN)=CC=1>>[C:16]([C:4]1[CH:3]=[C:2]([NH2:1])[N:6]([C:7]2[CH:8]=[CH:9][C:10]([O:21][CH3:20])=[CH:14][CH:15]=2)[N:5]=1)([CH3:17])([CH3:18])[CH3:19]

참가 물질

반응물 2

HCID 77023(4-Methoxyphenyl)hydrazine

HCID 9746884-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid

생성물 1

HCID 111393953-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-amine

실험 절차

The title compound was prepared in the same manner as described for 4-(5-amino-3-tert-butyl-pyrazol-1-yl)benzoic acid, replacing 4-hydrazinobenzoic acid with 4-methoxyphenylhydrazine. 1H-NMR (DMSO-d6) δ 7.40 (d, J=5.1 Hz, 2H), 6.98 (d, J=4.8 Hz, 2H), 5.32 (s, 1H), 5.05 (s, 2H), 3.77 (s, 3H), 1.20 (s, 9H); MS LC-MS [M+H]+=246, RT=1.76 min.

출처 및 근거

ORD 기록: ord-77577e98dfe24fb49cdc7489cbd5e1a9
출처 데이터셋: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08207166B2

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