N-(2-Aminoethyl)isoquinoline-5-sulfonamide → Isoquinoline-5-sulfonic acid {2-[2-(4-bromo-2-isoxazol-5-yl-phenoxy)-ethylamino]-ethyl}-amide
반응식
CC(C[AlH]CC(C)C)C.CO[C:12](=O)[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([Br:21])=[CH:17][C:16]=1[C:22]1[O:26][N:25]=[CH:24][CH:23]=1.[NH2:28][CH2:29][CH2:30][NH:31][S:32]([C:35]1[C:36]2[CH:37]=[CH:38][N:39]=[CH:40][C:41]=2[CH:42]=[CH:43][CH:44]=1)(=[O:34])=[O:33]>>[Br:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][CH2:13][CH2:12][NH:28][CH2:29][CH2:30][NH:31][S:32]([C:35]2[C:36]3[CH:37]=[CH:38][N:39]=[CH:40][C:41]=3[CH:42]=[CH:43][CH:44]=2)(=[O:34])=[O:33])=[C:16]([C:22]2[O:26][N:25]=[CH:24][CH:23]=2)[CH:17]=1참가 물질
4
실험 절차
By following a similar procedure as described in Example 34, DIBAL-H reduction of (4-bromo-2-isoxazol-5-yl-phenoxy)-acetic acid methyl ester, and subsequent reductive amination with isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide gives the free amine of the title compound as a white solid. ESIMS: m/z 517 [(M+H)+, 79Br], 519 [(M+H)+, 81Br].
출처 및 근거
- ORD 기록
- ord-5f8380b4ed044931a993709dd4f142d0
- 출처 데이터셋
- uspto-grants-2008_08
- 특허 번호
- US07414063B2
반응 노트
불러오는 중…