2-Chloropyrimidine → HCID 23726021, 화합물

HRID 2219346노트

반응식

[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:13]([C:14]3[N:15]=[CH:16][NH:17][CH:18]=3)=[C:12]([CH3:19])[O:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].Cl[C:21]1[N:26]=[CH:25][CH:24]=[CH:23][N:22]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:13]([C:14]3[N:15]=[CH:16][N:17]([C:21]4[N:26]=[CH:25][CH:24]=[CH:23][N:22]=4)[CH:18]=3)=[C:12]([CH3:19])[O:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

반응물 2

HCID 744042-Chloropyrimidine

HCID 178435006HCID 178435006, 화합물

생성물 1

HCID 23726021HCID 23726021, 화합물수율 47%

실험 절차

As described for Example 53, 3-(3,4-difluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methyl-isoxazole (78 mg, 0.3 mmol) using 2-chloropyrimidine instead of 4-fluoroacetophenone was converted to the title compound (48 mg, 47%) which was obtained as an off-white solid. MS: m/e=406.3 [M+H]+.

출처 및 근거

ORD 기록: ord-700c9c3cbcc349b69156e5098f94216f
출처 데이터셋: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07414061B2

반응 노트

불러오는 중…