3-Tolylboronic acid → HCID 23725747, 화합물

반응식

[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[C:19]1([CH3:28])[CH:24]=[CH:23][CH:22]=[C:21](B(O)O)[CH:20]=1>>[F:18][C:15]1[CH:16]=[CH:17][C:12]([C:7]2[C:6]([C:4]3[N:3]=[CH:2][N:1]([C:21]4[CH:20]=[C:19]([CH3:28])[CH:24]=[CH:23][CH:22]=4)[CH:5]=3)=[C:10]([CH3:11])[O:9][N:8]=2)=[CH:13][CH:14]=1

참가 물질

반응물 2

HCID 27339503-Tolylboronic acid

HCID 178434995HCID 178434995, 화합물

생성물 1

HCID 23725747HCID 23725747, 화합물수율 17%

실험 절차

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-(4-fluorophenyl)-isoxazole (73 mg, 0.3 mmol) was converted, using m-tolylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (17 mg, 17%) which was obtained as an off-white solid. MS: m/e=334.3 [M+H]+.

출처 및 근거

ORD 기록: ord-f0ee019c8c184b578e0f6a1fafcfa98f
출처 데이터셋: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07414061B2

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