1-Bromo-3,5-difluorobenzene → HCID 11653072, 화합물

반응식

[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[C:15]([NH:16]C3C=NC=CC=3)=[CH:14][CH:13]=[C:12]([CH3:23])[N:11]=2)=[O:9])=[N:3]1.Br[C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[C:27]([F:32])[CH:26]=1>>[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[C:15]([NH:16][C:25]3[CH:30]=[C:29]([F:31])[CH:28]=[C:27]([F:32])[CH:26]=3)=[CH:14][CH:13]=[C:12]([CH3:23])[N:11]=2)=[O:9])=[N:3]1

참가 물질

반응물 2

HCID 1363131-Bromo-3,5-difluorobenzene

HCID 11573128HCID 11573128, 화합물

생성물 1

HCID 11653072HCID 11653072, 화합물

실험 절차

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide (example 16) in accordance with the general method of example 20 using 1-Bromo-3,5-difluorobenzene instead of 3-Bromo-4-methylpyridine to yield the final compound as a light yellow solid, MS (ISP): m/e=344.0 (M+H+).

출처 및 근거

ORD 기록: ord-3588cb3accb14cde8d80c3807d4650c9
출처 데이터셋: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07414060B2

반응 노트

불러오는 중…