Trifluoroacetic acid → 1,2,3,6-Tetrahydro-4-[3-(methylthio)phenyl]pyridine

HRID 2220095

반응식

HRID 2220095 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20][CH3:21])[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:21][S:20][C:16]1[CH:15]=[C:14]([C:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=2)[CH:19]=[CH:18][CH:17]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 129889644-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic acid tert-butyl ester

생성물 1

HCID 129889651,2,3,6-Tetrahydro-4-[3-(methylthio)phenyl]pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Hydroxy-4-(3-methylsulfanyl-phenyl)-piperidin-1-carboxylic acid tert-butyl ester (3.97 g) was dissolved in CH2Cl2 (500 ml) and trifluoroacetic acid (80 ml) was added in one portion. The mixture was refluxed for one hour and then washed with two portions of 10%-Na2CO3, dried (MgSO4), filtered and evaporated to dryness. Yield 2.07 g. MS m/z (relative intensity, 70 eV) 205 (M+, 73), 158 (44), 129 (95), 128 (80), 82 (bp).

후처리

  1. temperatureThe mixture was refluxed for one hour
  2. washwashed with two portions of 10%-Na2CO3
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-f3519a99f49b4cc4813845475c58d895
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07417043B2

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