2-Methyl-5-nitroquinoline → 5-Quinolinamine, 2-methyl-
반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N+:12]([O-])=O)[N:3]=1.[H][H]>[Pd].C(O)(=O)C>[NH2:12][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[CH:10]=[CH:11][C:2]([CH3:1])=[N:3]2참가 물질
5
실험 절차
2-Methyl-5-nitroquinoline (25 g, 132.85 mmol) and palladium on carbon (2.5 g) in 8 ml of glacial acetic acid are stirred for 5½ hours in a hydrogen atmosphere at normal pressure. The catalyst is suctioned off and washed with ethyl acetate. The combined filtrates are concentrated by evaporation. Column chromatography of the residue on silica gel with dichloromethane-acetone yields 10.6 g of the product.
후처리
- washwashed with ethyl acetate
- concentrationThe combined filtrates are concentrated by evaporation
출처 및 근거
- ORD 기록
- ord-95a717b61b4a425e9911bd9ad99529df
- 출처 데이터셋
- uspto-grants-2008_08
- 특허 번호
- US07417056B2
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