2-Methyl-5-nitroquinoline → 5-Quinolinamine, 2-methyl-

HRID 2220239

반응식

HRID 2220239 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N+:12]([O-])=O)[N:3]=1.[H][H]>[Pd].C(O)(=O)C>[NH2:12][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[CH:10]=[CH:11][C:2]([CH3:1])=[N:3]2

참가 물질

5

반응물 2

HCID 2948672-Methyl-5-nitroquinolineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 1486835-Quinolinamine, 2-methyl-수율 50.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

2-Methyl-5-nitroquinoline (25 g, 132.85 mmol) and palladium on carbon (2.5 g) in 8 ml of glacial acetic acid are stirred for 5½ hours in a hydrogen atmosphere at normal pressure. The catalyst is suctioned off and washed with ethyl acetate. The combined filtrates are concentrated by evaporation. Column chromatography of the residue on silica gel with dichloromethane-acetone yields 10.6 g of the product.

후처리

  1. washwashed with ethyl acetate
  2. concentrationThe combined filtrates are concentrated by evaporation

출처 및 근거

ORD 기록
ord-95a717b61b4a425e9911bd9ad99529df
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07417056B2

연결된 노트

불러오는 중…