참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Nitrofungin | HCID 12074 | — |
| 반응물 | Hydrogen chloride dimer | HCID 6410751 | — |
| 생성물 | 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine | HCID 17469433 | 52% |
반응 단계
2-chloro-4-nitro phenol 10 g (57.6 mmol, 1 eq), 2-pycolyl chloride hydrogen chloride 9.45 g (57.6 mmol, 1 equiv) cesium carbonate 41.3 (126.8 mmol, 2.2 equiv) and sodium iodide 8.64 g (57.6 mmol, 1 equiv) were suspended in 200 mL acetonitrile. The reaction mixture was stirred at 60° C. for 5 h. The resulted suspension was filtered and washed with 400 mL water, yielding 2-(2-chloro-4-nitro-phenoxymethyl)-pyridine (8 g, 52%) as a red solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08207172B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_06 |
|---|
| ORD ID | ord-b1c8e9d82ccb4ffdab9f980fd3450f46 |
|---|
| 출처 메모 | uspto-grants-2012_06 |
|---|
