Ammonium Hydroxide → 4-Bromo-2-fluorobenzenesulphonamide
반응식
[OH-].[NH4+:2].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[C:6]([F:14])[CH:5]=1>ClCCl>[Br:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:2])(=[O:12])=[O:11])=[C:6]([F:14])[CH:5]=1참가 물질
4
실험 절차
To a ammonium hydroxide (28%, 80 ml) was added a solution of 4-bromo-2-fluorobenzenesulfonyl chloride (10 g) in dichloromethane (80 ml) dropwise for 1 hour at approximately 0° C. The reaction mixture was stirred vigorously for an additional 2 hours at the same temperature. The phases were separated. The aqueous phase was washed with dichloromethane. The combined organic extracts were washed with brine, dried over sodium sulfate and evaporated to give 4-bromo-2-fluorobenzenesulfonamide (8.0 g).
후처리
- customThe phases were separated
- washThe aqueous phase was washed with dichloromethane
- washThe combined organic extracts were washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
출처 및 근거
- ORD 기록
- ord-811634a4ef184929b379d0bad9fb230e
- 출처 데이터셋
- uspto-grants-2008_08
- 특허 번호
- US07417060B2
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