참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Nitroindazole | HCID 21501 | — |
| 반응물 | 3-Fluorobenzyl bromide | HCID 68007 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-[(3-Fluorophenyl)methyl]-5-nitroindazole | HCID 21049421 | 37% |
| 생성물 | 1-(3-fluorobenzyl)-5-nitro-1H-indazole | HCID 21966490 | 32% |
반응 단계
5-nitroindazole (15 g, 92 mmol, 1 eq), 3-fluorobenzylbromide (14.7 mL, 119.5 mmol, 1.3 eq) and potassium carbonate 25.4 g (184 mmol, 2 equiv) were suspended in 150 mL acetonitrile. The reaction mixture was stirred at 70° C. for 12 h, and then allowed to cool to rt. The resultant solid was filtered and washed with CH2Cl2, and the filtrate concentrated in vacuo. The crude mixture of regioisomeric products was purified by column chromatography (5:1 to 4:1 Hex/EtOAc), yielding 5-nitro-1-N-(3-fluorobenzyl)indazole (7.9 g, 32%) and 5-nitro-2-N-(3-fluorobenzyl)indazole (9.2 g, 37%) as yellow solids.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08207172B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_06 |
|---|
| ORD ID | ord-ccedf090936f47639c8c200e442da7b6 |
|---|
| 출처 메모 | uspto-grants-2012_06 |
|---|
