Water → Benzyl 4-benzoyloxy-2-benzyloxybenzoate

HRID 2220600노트

반응식

HRID 2220600 반응식
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]([O:17][C:18]1[CH:33]=[CH:32][C:21]([C:22]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:23])=[C:20]([OH:34])[CH:19]=1)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C)C=O>[C:9]([O:17][C:18]1[CH:33]=[CH:32][C:21]([C:22]([O:24][CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)=[O:23])=[C:20]([O:34][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:19]=1)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 10796Cesium carbonateHCID 23134101Benzyl 4-benzoyloxy-2-hydroxybenzoate

생성물 1

HCID 23090801Benzyl 4-benzoyloxy-2-benzyloxybenzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Benzyl bromide (0.80 mL) was added to a mixture of benzyl 4-benzoyloxy-2-hydroxybenzoate (2.23 g) and cesium carbonate (2.29 g) in N,N-dimethylformamide (10 mL) at room temperature with stirring, and the mixture was stirred at 50° C. for 3 hrs. Water was added to the reaction mixture, and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by medium-pressure silica gel column chromatography (eluent: n-hexane/ethyl acetate=6/1) to afford benzyl 4-benzoyloxy-2-benzyloxybenzoate (2.87 g).

후처리

  1. stirringthe mixture was stirred at 50° C. for 3 hrs
  2. extractionthe resulting mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water and brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure
  6. customthe residue was purified by medium-pressure silica gel column chromatography (eluent: n-hexane/ethyl acetate=6/1)

출처 및 근거

ORD 기록
ord-236a8b25aeea442bb63ca33203f5bd4c
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07417169B2

반응 노트

불러오는 중…