HCID 69201908, 화합물 → 4'-{2-[(1S,2R)-2-Hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)-1-methylethylamino]ethoxy}-3',5'-dimethylbiphenyl-4-carboxylic acid

HRID 2220657노트

반응식

HRID 2220657 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([OH:46])[C@@H:16]([NH:18][CH2:19][CH2:20][O:21][C:22]2[C:27]([CH3:28])=[CH:26][C:25]([C:29]3[CH:34]=[CH:33][C:32]([C:35]([O:37]CC4C=CC=CC=4)=[O:36])=[CH:31][CH:30]=3)=[CH:24][C:23]=2[CH3:45])[CH3:17])=[CH:11][C:10]=1[NH:47][S:48]([CH3:51])(=[O:50])=[O:49])C1C=CC=CC=1>CN(C)C=O.[C].[Pd]>[OH:46][C@H:15]([C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([NH:47][S:48]([CH3:51])(=[O:50])=[O:49])[CH:11]=1)[C@@H:16]([NH:18][CH2:19][CH2:20][O:21][C:22]1[C:27]([CH3:28])=[CH:26][C:25]([C:29]2[CH:34]=[CH:33][C:32]([C:35]([OH:37])=[O:36])=[CH:31][CH:30]=2)=[CH:24][C:23]=1[CH3:45])[CH3:17]

참가 물질

4

반응물 1

HCID 69201908HCID 69201908, 화합물

생성물 1

HCID 692010834'-{2-[(1S,2R)-2-Hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)-1-methylethylamino]ethoxy}-3',5'-dimethylbiphenyl-4-carboxylic acid수율 65.2%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 6228Dimethylformamide용매

실험 절차

To a solution of benzyl 4′-{2-[(1S,2R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxy-1-methylethylamino]ethoxy}-3′,5′-dimethylbiphenyl-4-carboxylate (0.074 g) in N,N-dimethylformamide (4 mL) was added 10% palladium-carbon (0.05 g), and the mixture was stirred at room temperature for 1.5 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the solvent was evaporated under reduced pressure. Methylene chloride was added to the residue, and the resulting precipitated materials were collected by filtration. The crude product was purified by ODS column chromatography (eluent: acetonitrile/water=1/1) to afford the title compound (0.036 g).

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated under reduced pressure
  3. additionMethylene chloride was added to the residue
  4. customthe resulting precipitated materials
  5. filtrationwere collected by filtration
  6. customThe crude product was purified by ODS column chromatography (eluent: acetonitrile/water=1/1)

출처 및 근거

ORD 기록
ord-f9ab299eb7f74fb3b504ee48d301918b
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07417169B2

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