HCID 69204095, 화합물 → HCID 69201523, 화합물
반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([OH:36])[CH2:16][NH:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([OH:35])=[O:34])=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)=[CH:11][C:10]=1[NH:37][S:38]([CH3:41])(=[O:40])=[O:39])C1C=CC=CC=1>CN(C)C(=O)C.[C].[Pd]>[OH:36][C@H:15]([C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([NH:37][S:38]([CH3:41])(=[O:40])=[O:39])[CH:11]=1)[CH2:16][NH:17][CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]([OH:35])=[O:34])=[CH:31][CH:32]=2)=[CH:23][CH:22]=1참가 물질
4
실험 절차
A suspension of the crude 4′-{2-[(R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxyethylamino]ethoxy}biphenyl-4-carboxylic acid and 10% palladium-carbon (0.03 g) in N,N-dimethylacetamide (5 mL) was stirred at room temperature for 2 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the solvent was evaporated under reduced pressure. The residue was triturated in methylene chloride, and then dissolved by addition of acetonitrile (5 mL) and water (5 mL) The insoluble materials were removed by filtration, and the solvent was evaporated under reduced pressure to afford the title compound (0.045 g).