Uridine Diphosphate → 5'-Adp

HRID 2220826

반응식

HRID 2220826 반응식
C([N:5](CCCC)CCCC)CCC.[CH:14]1[C:20](=O)[NH:19][C:17](=O)[N:16]([C@@H:22]2[O:26][C@H:25]([CH2:27][O:28][P:29]([O:32][P:33]([OH:36])([OH:35])=[O:34])([OH:31])=[O:30])[C@@H:24]([OH:37])[C@H:23]2[OH:38])[CH:15]=1.[CH:39]1[C:45](=[O:46])[NH:44][C:42](=[O:43])[N:41]([C@@H:47]2[O:51][C@H:50]([CH2:52][O:53][P:54]([O:57][P:58]([O-:61])([OH:60])=[O:59])([O-:56])=[O:55])[C@@H:49]([OH:62])[C@H:48]2[OH:63])[CH:40]=1.[Na+].[Na+]>CCO>[P:29]([O:28][CH2:27][C@H:25]1[O:26][C@@H:22]([N:16]2[C:15]3[N:44]=[CH:42][N:41]=[C:20]([NH2:19])[C:14]=3[N:5]=[CH:17]2)[C@H:23]([OH:38])[C@@H:24]1[OH:37])([O:32][P:33]([OH:35])([OH:36])=[O:34])(=[O:30])[OH:31].[CH:39]1[C:45](=[O:46])[NH:44][C:42](=[O:43])[N:41]([C@@H:47]2[O:51][C@H:50]([CH2:52][O:53][P:54]([O:57][P:58]([OH:60])([OH:61])=[O:59])([OH:56])=[O:55])[C@@H:49]([OH:62])[C@H:48]2[OH:63])[CH:40]=1

참가 물질

6

반응물 3

HCID 6031Uridine DiphosphateHCID 7622Tributylamine2회HCID 11957711Disodium uridine 5'-diphosphate

생성물 2

HCID 60225'-AdpHCID 6031Uridine Diphosphate

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

ADP (Bu3NH+)2, AMP (Bu3NH+)2 and UMP (Bu3NH+)2 were prepared from the corresponding free acid and tributylamine (Bu3N; 2 eq) in EtOH. UDP (Bu3NH+)2 was prepared from UDP disodium salt. The latter salt was passed through a column of activated Dowex 50WX-8 200 mesh, H+ form. The column eluate was collected in an ice-cooled flask containing (Bu3N (2 eq) and EtOH. The resulting solution was freeze-dried to yield UDP (Bu3NH+)2 as a viscous oil.

후처리

  1. customThe column eluate was collected in an ice-
  2. temperaturecooled flask
  3. customThe resulting solution was freeze-dried

출처 및 근거

ORD 기록
ord-6cb1e4da4e8c460fa6412f7058e95f22
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07368439B2

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