2-Oxo-[1,4']bipiperidinyl-1'-carboxylic acid benzyl ester → [1,4'-Bipiperidin]-2-one

HRID 2221081노트

반응식

HRID 2221081 반응식
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][C:18]2=[O:23])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].C(O)C>[N:17]1([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH2:22][CH2:21][CH2:20][CH2:19][C:18]1=[O:23]

참가 물질

4

반응물 1

HCID 233699802-Oxo-[1,4']bipiperidinyl-1'-carboxylic acid benzyl ester

생성물 1

HCID 21839852[1,4'-Bipiperidin]-2-one

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

2-Oxo-[1,4′]bipiperidinyl-1′-carboxylic acid benzyl ester (2.5 g) and Pearlman's catalyst (0.50 g) was stirred in ethanol (30 mL) under hydrogen (1 atm). After 20 hours the reaction as filtered through celite and concentrated. The title compound was obtained as a white solid (1.45 g). MS: m/z=183 (M+H).

후처리

  1. customAfter 20 hours the reaction
  2. filtrationas filtered through celite and
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-cad510d22ef144e9bbc92fbeab35ec16
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07368461B2

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