Acetonitrile → 1-(2-Fluoro-5-pyridylmethyl) 2-(nitroimino)imidazolidine

HRID 22211노트

반응식

HRID 22211 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Br)=[CH:4][N:3]=1.[N+:10]([N:13]=[C:14]1[NH:18][CH2:17][CH2:16][NH:15]1)([O-:12])=[O:11].C(=O)([O-])[O-].[K+].[K+].C(#N)C>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:15]2[CH2:16][CH2:17][NH:18][C:14]2=[N:13][N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1

참가 물질

6

반응물 4

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 220506385-(Bromomethyl)-2-fluoropyridineHCID 135413413N-nitroimidazolidin-2-imine

생성물 1

HCID 1363427881-(2-Fluoro-5-pyridylmethyl) 2-(nitroimino)imidazolidine수율 50.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2-fluoro-5-pyridylmethyl bromide (9.5 g), 2-(nitroimino)imidazolidine (6.5 g), potassium carbonate (7.6 g) and acetonitrile (100 ml) was refluxed for 2 hours with stirring. After the reaction, the reaction mixture was cooled to room temperature, and cold water (100 ml) was added. The resulting crystals were collected by filtration and washed with ether to give slightly colored 1-(2-fluoro-5-pyridylmethyl)-2-(nitroimino)imidazolidine (6.0 g) as the desired compound.

후처리

  1. temperaturewas refluxed for 2 hours
  2. customAfter the reaction
  3. filtrationThe resulting crystals were collected by filtration
  4. washwashed with ether

출처 및 근거

ORD 기록
ord-ebb2b9f9fe42400aa8d3315b4666b29b
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428032

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