Pyridine → 3-(6-Methyl-pyridin-2-yl)-3-(2-oxo-pyrrolidin-1-ylimino)-propionic Acid Ethyl Ester

HRID 2221144노트

반응식

HRID 2221144 반응식
Cl.[NH2:2][N:3]1[CH2:7][CH2:6][CH2:5][C:4]1=[O:8].[CH2:9]([O:11][C:12](=[O:23])[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=1)=O)[CH3:10].N1C=CC=CC=1>O>[CH2:9]([O:11][C:12](=[O:23])[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=1)=[N:2][N:3]1[CH2:7][CH2:6][CH2:5][C:4]1=[O:8])[CH3:10]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 219928451-Aminopyrrolidin-2-one hydrochlorideHCID 59710028Ethyl 3-(6-methylpyridin-2-yl)-3-oxopropanoate

생성물 1

HCID 597100333-(6-Methyl-pyridin-2-yl)-3-(2-oxo-pyrrolidin-1-ylimino)-propionic Acid Ethyl Ester

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Add 1-aminopyrrolidin-2-one hydrochloride (Zubek, A. Z. Chem. 1969, 9(2), 58; 99.4 g, 0.73 mol) to a 3 L flask equipped with mechanical stirrer and nitrogen inlet. Add 3-[6-methyl-(pyridin-2-yl)]-3-oxo-propionic acid ethyl ester (154 g, 0.66 mol), and pyridine (280 mL). Stir the reaction mixture at room temperature for 20 h. Dilute the mixture with water (200 mL) and extract with toluene (2×250 mL). Combine the organic layers, filter, and concentrate in vacuo to yield the subtitled product (201 g) as a dark oil. MS ES+ m/e 290 (M+1).

후처리

  1. custom99.4 g, 0.73 mol) to a 3 L flask equipped with mechanical stirrer and nitrogen inlet
  2. extractionextract with toluene (2×250 mL)
  3. filtrationCombine the organic layers, filter
  4. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-c12874eff9284e05a25ef5a8a9f8189a
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07368445B2

반응 노트

불러오는 중…