Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 22213생성일: 2026년 10월 23일
2,2,2-Trifluoroethanol → 1-[2-(2,2,2-Trifluoroethoxy)-5-pyridylmethyl]-2-(nitroimino)imidazolidine
https://huagongshe.com/ko/reaction/22213
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2,2,2-Trifluoroethanol sodium salt | HCID 86742142 | — |
| 반응물 | 1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine | HCID 135527764 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-[2-(2,2,2-Trifluoroethoxy)-5-pyridylmethyl]-2-(nitroimino)imidazolidine | HCID 136342790 | 23.6% |
반응 단계
Sodium hydride (0.48 g) was added to a solution of 2,2,2-trifluoroethanol (2.4 g) in toluene (30 ml) was added, and the mixture was stirred until the generation of hydrogen ceased. As a result, 2,2,2-trifluoroethanol sodium salt was prepared. To the product were added 1-(2-chloro-5-pyridylmethyl)-2-(nitroimino)imidazolidine (5.1 g) synthesized by the method of Example 3 and a catalytic amount of 4-dimethylaminopyridine. The mixture was heated at 80° C. for 10 hours with stirring. After cooling the reaction mixture, the precipitated crystals were collected by filtration, washed with water and ether and then purified by silica gel chromatography to give 1-[2-(2,2,2-trifluoroethoxy)-5-pyridylmethyl]-2-(nitroimino)imidazolidine (1.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05428032 |
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| 출처 데이터셋 | uspto-grants-1995_06 |
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| ORD ID | ord-37f501ed7b344cf2b37eaf2f0fd15b97 |
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| 출처 메모 | uspto-grants-1995_06 |
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